The Great Cleric manga tells the story of Luciel, an overworked salaryman from Japan who unexpectedly dies and is reincarnated in the magical world of Galdardia. His new life is the result of a divine wager between the God of Fate from Earth and the Chief God of Galdardia. Despite being an ordinary soul, Luciel is granted a unique ability by the Chief God, giving him a chance to live once again. Instead of choosing a flashy or powerful path, Luciel decides to become a healer, aiming to carve out a peaceful and prosperous life in this strange and unfamiliar world.

Though Luciel is adept at business and hard work, his knowledge of Galdardia is almost non-existent, making his journey all the more challenging. However, through persistence, discipline, and a good heart, he begins to build a name for himself, slowly transforming into a revered figure known as The Great Cleric. His story is a blend of personal growth, hard-earned success, and the occasional divine interference, making it a compelling tale of self-reinvention in a fantastical setting.